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Aging will soon be a choice as scientists close in on the fountain of youth

Aging will soon be a choice as scientists close in on the fountain of youth

People will soon be able to decide when they want to age, or even age at all as scientists close in on the fountain of youth.

Scientists at Haifa’s Rambam Health Care Campus and the Technion-Israel Institute of Technology and colleagues abroad in a new study recently published in Science Advances say they have found a way to make elderly human skin young again after two decades of research.


This seems to be a breakthrough as the scientists were able to achieve this in lab rodents, which provides a glipse of the possibility that aging will soon be a choice as they close in on the fountain of youth.

Aging is a gradual, continuous process of natural change that begins in early adulthood. Many body processes start to gradually deteriorate in the early middle years. At no particular age do people become old or elderly.

People frequently question whether their aging-related experiences are normal or abnormal. Despite the fact that everyone ages somewhat differently, aging itself can cause various changes. Therefore, despite being undesirable, such changes are thought to be normal and are frequently referred to as pure aging.

Everyone who lives long enough experiences these changes, and the notion of pure aging includes this universality. The modifications are normal and usually unavoidable.

But have you ever wished for a day when you might have the power to choose to grow old or return to your youthful self? Well, this omnipresent human desire seems closer to fulfillment, at least in laboratory mice, on whom scientists discovered a mechanism for rejuvenating human organs.

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Aging will soon be a choice as scientists close in on the fountain of youth

The scientists found that it is feasible to restore youth to the skin and other organs. This is done by altering the molecular structure of the skin throughout all of its layers in mice. This will be done using an old skin transplant.

The findings showed that the transplantation of living cells, tissues or organs from one species to another can be rejuvenated by placing old human skin on young mice with the severe combined immunodeficiency disease (SCID), which genetically affects both B and T lymphocytes.

This is accompanied by angiogenesis, which is the development of new blood vessels, repigmentation of the epidermis, which is the skin’s outer layer and notable improvements in key aging-related indicators.

The scientists lay out the most fundamental missions of biomedical research. This involves dissecting the key drivers of human organ aging. It also includes developing efficient molecular plans to overcome it or even reverse it. That is, if one accepts the notion that aging is “an ultimately fatal disease. That is, whose progress can be slowed and reversed. Also, if one views aging as a druggable and reprogrammable target.”


Aging-research model

To do this, the scientists stressed that it is prudent to develop an aging-research model. This model can be used to identify the major factors that contribute to human organ aging. Also, to test the most promising anti-aging medications on lab animals before being tried on humans.

Mainstream aging research rarely uses human skin as a preclinical aging study model. So, skin changes and graying hair are the first signs that a person is getting older.

Consequently, “massive industry efforts cater to the ancient human desire to stop or reverse the phenotype of aging skin.” This was according to the study’s authors.

“Success at this frontier has been, at best, moderate, and most product claims that human skin can be rejuvenated in-vivo [in animal models] are not well supported. The molecular pathways that cause skin to age in lab animals, on the other hand, are becoming clearer and seem possible,” the scientists added.

How they did it

The scientists had previously transplanted old human skin into SCID young mice. However, they were unsure if the skin renewal they had observed went deeper than the epidermis. In order to ascertain this, vascular endothelial growth factor A (VEGF-A) was employed to encourage the rejuvenation of human organs in lab animals.

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Old human skin was transplanted onto young SCID mice. The aging was reversed, proving that all layers of human skin can become young again. Additionally, there was an increase in the number of new blood vessels in the skin.

The study, “Human organ rejuvenation by VEGF-A: Lessons from the skin,” was authored by Dr. Aviad Keren, Dr. Yaniv Keren, Prof. Yehuda Ullman, Prof. Amos Gilhar, Dr. Marta Bertolini and Dr. Ralf Paus.

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